Fri Dec 30 2022

45 articles - From Friday Dec 23 2022 to Friday Dec 30 2022

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Kidney Dis

Blood Pressure Classification Status in Children With CKD Following Adoption of the 2017 American Academy of Pediatrics Guideline.

A greater percentage of children with CKD were identified as hypertensive based on both clinic and ambulatory blood pressure when using the 2017 vs the 2004 guidelines, and the 2017 guidelines better discriminated those with higher levels of proteinuria. The substantial differences in the classification of hypertension when using the 2004 vs 2017 guidelines should inform clinical care.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Association of an Acute Kidney Injury Follow-up Clinic With Patient Outcomes and Care Processes: A Cohort Study.

Specialized post-discharge follow-up for AKI survivors was not associated with a lower risk of major adverse kidney events but was associated with a lower risk of death and increased prescriptions for some cardioprotective medications.

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How Do Kidney Disease Clinicians View Kidney Supportive Care and Palliative Care? A Qualitative Study.

Kidney clinicians described systemic challenges and compromises in care experiences and the need for development of kidney supportive care services. They expressed that this development would require a consistent and systematic approach that integrates palliative care and embeds kidney supportive care as part of kidney health service delivery.

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Sex and Gender in Randomized Controlled Trials of Adults Receiving Maintenance Dialysis: A Meta-epidemiologic Study.

RCTs in dialysis are representative of the general dialysis population with regard to sex and gender but uncommonly report both, and often do not include either in their reporting or analysis.

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Venglustat, a Novel Glucosylceramide Synthase Inhibitor, in Patients at Risk of Rapidly Progressing ADPKD: Primary Results of a Double-Blind, Placebo-Controlled, Phase 2/3 Randomized Clinical Trial.

In patients with rapidly progressing ADPKD, treatment with venglustat at either 8 mg or 15 mg showed no change in the rate of change in TKV and a faster rate of eGFR decline in the STAGED-PKD trial despite a dose-dependent decrease in plasma glucosylceramide (GL-1) levels.

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Clin J Am Soc Nephrol

Maintenance of Remission and Risk of Relapse in Myeloperoxidase Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Kidney Involvement.

Persistence or subsequent reappearance of MPO-ANCA is associated with an increased risk of relapse. Serial MPO-ANCA determinations can inform the development of remission-maintenance strategies in patients with MPO-ANCA associated vasculitis with glomerulonephritis.

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J Am Soc Nephrol

Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.

-mediated active cytosine hydroxymethylation in NPCs play a key role in kidney development and nephron endowment.

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HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.

HNF1B activates an evolutionarily conserved program of target genes that disease-causing mutations selectively disrupt. These findings provide insights into the renal transcriptional network that controls nephrogenesis.

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Kidney Int

Individuals heterozygous for ALG8 protein-truncating variants are at increased risk of a mild cystic kidney disease.

ALG8 PTVs were not associated with chronic kidney disease or kidney failure in the MyCode study or the UK Biobank data. Thus, PTVs in ALG8 result in increased risk of a mild cystic kidney disease phenotype.

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Machine learning does not outperform traditional statistical modelling for kidney allograft failure prediction.

Thus, when using a transparent methodological pipeline in validated international cohorts, ML models, despite overall good performances, do not outperform a traditional CBPS in predicting kidney allograft failure. Hence, our current study supports the continued use of traditional statistical approaches for kidney graft prognostication.

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Mapping the T cell epitopes of the M-type transmembrane phospholipase A2 receptor in primary membranous nephropathy.

Thus, we mapped and identified ten peptides in the CysR, FnII, CTLD3, CTLD5, CTLD7 domains of PLA2R as potential T-cell epitopes of MN. These findings are a first step towards developing peptide-specific immunotherapies.

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The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury.

Thus, increased proximal tubular Fosl1 expression during AKI is an adaptive response, preserves Klotho. and limits the severity of tubular cell injury and AKI.

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Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development.

Thus, our study demonstrates that HIV Vpr expression in tubular cells is sufficient to induce HIVAN-like tubulointerstitial damage and fibrosis, independent of glomerulosclerosis and proteinuria. Additionally, as this new mouse model develops progressive CKD with diffuse fibrosis and kidney failure, it can serve as a useful tool to examine the mechanisms of kidney disease progression and fibrosis in vivo.

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Untargeted Metabolomics of Perfusate and Their Association with Pump Perfusion and Allograft Failure.

On interrogation of pathway analysis, production of reactive oxygen species and increased metabolism of fatty acids were upregulated in kidneys that subsequently developed death-censored graft failure. Thus, further understanding the role of these metabolites may inform the HMP process and help improve the objective evaluation of allograft offers, thereby reducing the discard of potentially viable organs.

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Nephrol Dial Transplant

Analysis of on-treatment cancer safety events with daprodustat versus conventional erythropoiesis-stimulating agents - post hoc analyses of the ASCEND-ND and ASCEND-D trials.

Prespecified on-treatment analyses for cancer-related AEs appeared to result in biased risk estimates in ASCEND-ND by preferentially under-counting events from patients assigned to darbepoetin. Analyses accounting for longer darbepoetin dosing intervals, or extending follow-up, resulted in attenuation of effect estimates towards neutrality, similar to ASCEND-D, where ESA comparator dosing intervals are closer to daprodustat.

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Dietary lithium intake, graft failure and mortality in kidney transplant recipients.

Dietary lithium intake may be a potentially modifiable-yet rather overlooked-risk factor for adverse long-term kidney graft outcomes and patient survival.

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Early acute kidney injury is associated with in-hospital adverse outcomes in critically ill burn patients: an observational study.

The KDIGO guidelines criteria are useful to diagnose AKI in burn patients. Even the mild form of AKI is independently associated with increased mortality. Considering the UO criterion is important to more accurately assess the incidence of AKI, but AKI meeting UO criterion alone is not associated with increased mortality.

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Effect of residual kidney function and dialysis adequacy on chronic pruritus in dialysis patients.

We found no association between dialysis Kt/V and CKD-aP. Higher residual eGFR and lower serum phosphate level, but not the dialysis dose, were related with lower burden of CKD-aP in dialysis patients.

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Efficacy and safety of interleukin-1 blockers in kidney transplant recipients with familial Mediterranean fever: a propensity score-matched cohort study.

When compared to pre-treatment period, with IL-1 blockers, number of attacks per month (p<0.001), eGFR (p = 0.004), hsCRP (p<0.001) and ESR (p = 0.026) levels were lower throughout the follow-up; whereas proteinuria levels were not. Anakinra and canakinumab are effective in KTRs suffering from FMF; however, mortality rate may be of concern.

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Fasting influences aquaporin expression, water transport and adipocyte metabolism in the peritoneal membrane.

Fasting induces a coordinated regulation of lipolytic and lipogenic factors and aqua(glycero)porins in the peritoneum, driving structural and functional changes. These data yield novel information on the specific roles of aquaporins in the peritoneal membrane and indicate that fasting improves fluid removal in a mouse model of PD.

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Genetic spectrum of CAKUT and risk factors for kidney failure: a pediatric multicenter cohort study.

The genetic spectrum of CAKUT varies among different subphenotypes. The identified factors indicate areas that require special attention.

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Malignancy risk in kidney transplant recipients exposed to immunosuppression pre-transplant for the treatment of glomerulonephritis.

The use of PTI for treatment of GN, especially cyclophosphamide or even with rituximab, is associated with increased risk for development of solid or hematologic malignancy post-transplant. These data highlight potential risks with treatment of GN and underscore the importance of post-transplant malignancy surveillance in this patient population.

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Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTR: results from two prospective cohort studies.

Plasma endotrophin is strongly associated with graft failure and mortality among KTR. These findings suggest a key role of abnormal extracellular matrix turnover and fibrosis in graft and patient prognosis among KTR, and highlight the need for (interventional) studies targeting the pro-fibrotic state of KTR. The intra-individual stability after transplantation indicates potential use of endotrophin as a biomarker and outcome measure of fibrosis.

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Sleep duration and cognitive function among older adults with chronic kidney disease - results from the National Health and Nutrition Examination Survey (2011-2014).

Longer sleep duration is associated with worse cognitive function only among persons with CKD and global cognition, delayed recall, and verbal fluency are particularly affected. Studies should identify interventions to improve sleep patterns and quality in this population.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

In Line.

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Much Ado About Something: The Clinical Pattern of Tolvaptan-Associated Liver Injury in Participants With ADPKD.

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Urine-to-Plasma Urea Ratio: Disentangling Tubular Concentrating Ability From GFR.

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Nephrol Dial Transplant

The need for a multi-disciplinary reflection about frailty and cognitive impairment in chronic kidney disease.

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Semin Nephrol

Controversies in Living Kidney Donation.

Furthermore, health care systems across the world also are funded with different levels of national and individual affordability, leading to health inequalities for the sick and risks of exploitation for the poor, especially through commercialization of transplantation. This article highlights some of these contemporary ethical concerns and controversies in living organ donation.

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Ethical Aspects of Kidney Donation and Transplantation for Migrants.

In this article, we discuss ethical obligations to provide kidney care for migrants, the implications of the self-sufficiency concept with regard to access to deceased donation and transplantation, factors that may influence evaluation of the risks and benefits of transplantation for migrants with insecure access to care, and the vulnerability of migrants to organ trafficking. We also present a set of general recommendations to assist in preventing and managing ethical dilemmas when making decisions about policy or practice regarding kidney care for migrants.

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Ethical Issues in Kidney Transplant and Donation During COVID-19 Pandemic.

In this article, we highlight some of the most important ethical questions that were raised during the pandemic and attempt to analyze ethical arguments in light of core principles of medical ethics to either suspend or continue kidney transplantation, and to mandate vaccination in transplant patients, transplant candidates, and, finally, health care providers. We have come up with frameworks to deal responsibly with these ethical challenges, and formulated recommendations to cope with the issues imposed on patients and transplant professionals.

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Ethical Issues Related to Donation and Transplantation of Donation After Circulatory Determination of Death Donors.

We discuss the controversies, challenges, and ethical and legal barriers in the acceptance of DCDD, including the complexities of implementing and sustaining controlled and uncontrolled DCDD donor programs. The lessons learned from global leaders will assist a wider international recognition, acceptance, and development of DCDD transplant programs that will noticeably facilitate and address the global shortages of kidneys for transplantation, and ensure the opportunity for people who had indicated their desires to become organ donors fulfill their final wishes.

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Introducing Incentives and Reducing Disincentives in Enhancing Deceased Organ Donation and Transplantation.

Perspectives from ethics, general public opinion, and the health care profession are examined to ensure a comprehensive appraisal and illustrate different facets of opinion on this complex area. Special cultural and psychosocial considerations in Asia, including the family based consent model, are discussed.

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Introduction: Kidney Donation and Transplantation: Ethics and Controversies.

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Kidney Organ Allocation System: How to Be Fair.

Here, we discuss the ethical challenges of creating a fair and equitable organ allocation system, focusing on the principles governing deceased donor kidney transplant waitlists around the world. The kidney organ allocation systems in the United States, Australia, and Hong Kong are used as illustrations.

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The Role of Registries in Kidney Transplantation Across International Boundaries.

Travel for transplantation presents significant challenges to the practice of transplantation medicine and donor medicine, but can be enhanced if sustainable international registries develop to include low- and low-middle income countries. Robust data collection and sharing across registries, linking pretransplant information to post-transplant information, linking donor to recipient information, increasing living donor transplant activity through paired exchange, and ongoing reporting of results to permit flexibility and adaptability to changing clinical environments, will al serve to enhance kidney transplantation across international boundaries.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Kidney Dis

Kidney Disease in a Patient With a Chronic Rash: A Quiz.

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Kidney Int

Soluble urokinase plasminogen activator receptor (suPAR) promotes atherosclerosis.

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Nat Rev Nephrol

Glucocorticoids block T cell recruitment.

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Insights into glomerular function and disease pathogenesis.

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Insights into the impact of pregnancy on kidney disease.

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Iron deficiency of kidney macrophages in CKD.

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Paths to organ damage and risk factors in AKI.

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Nephrol Dial Transplant

Association of environmental lead toxicity and hematologic outcomes in patients with advanced kidney disease.

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The foundation and the four pillars of treatment for cardiorenal protection in people with chronic kidney disease and type 2 diabetes.

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Letters&Replies

Letters to the editors and authors’ replies